• Spread: Bills (-7)
• Moneyline: Bills (-350); 49ers (+260)
• Over/under: 44.5

The Buffalo Bills can clinch the AFC East on Sunday night when they battle the injury-decimated San Francisco 49ers at Orchard Park, N.Y.

Buffalo (9-2) has won six straight games and is on the verge of a fifth consecutive AFC East crown. The Miami Dolphins (5-7) dropped a 30-17 decision to the Green Bay Packers on Thursday, a result that allows the Bills the chance to wrap up the division title with a win on Sunday.

Buffalo will be up against a San Francisco squad that may not have quarterback Brock Purdy for a second straight week.

Purdy was a limited practice participant on Wednesday and Thursday with the majority of his workload consisting of handoffs due to his ailing right shoulder. A full participant on Friday, Purdy is officially questionable for the game.

The 49ers (5-6) have lost back-to-back games entering a pivotal contest.

Buffalo had a bye last week following an impressive 30-21 home victory over the Kansas City Chiefs.

Buffalo is 3-2 against the spread, and 5-0 overall, at home.

The Bills have covered the spread seven times over 11 games with a set spread.

At home, Buffalo has one win ATS (1-2) as 6-point favorites or greater.

In games they have played as 6-point favorites or more, the Bills have an ATS record of 1-2.

In five home games this year, Buffalo has hit the over each time.

This season, Bills games have hit the over seven times.

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Bills vs. 49ers Recent Matchups

• San Francisco has a 3-2 record against Buffalo in their last five matchups.
• In their last five head-to-head matchups, San Francisco has scored 113 points against Buffalo, while giving up only 92 points.

Buffalo Betting Info

• Buffalo has played 11 games, posting seven wins against the spread.
• The Bills have covered the spread once when favored by 6 points or more this season (in three opportunities).
• Buffalo has combined with its opponent to hit the over in 63.6% of its contests this year (seven times in 11 games with a set point total).
• The Bills have not yet lost when playing as the moneyline favorite, going 8-0 in those matchups this season.
• The Bills have a 72.1% chance to win this game, based on the implied probability of the moneyline.

San Francisco got walloped last week without Purdy, falling 38-10 to the host Packers. Brandon Allen started at quarterback and completed 17 of 29 passes for 199 yards with one touchdown pass, one interception and one lost fumble.

Allen is 2-8 as an NFL starter. He received heavy work in practice in case Purdy’s shoulder doesn’t significantly improve.

The 49ers could use a big performance from running back Christian McCaffrey, who had just 31 yards on 11 carries and caught three passes for 37 yards against Green Bay.

McCaffrey missed the first eight games of the season with an Achilles tendon injury and has struggled to run the ball in his three appearances. He has 149 yards on 43 rushes for a paltry 3.5-yard average.

San Francisco Betting Info

• San Francisco has gone 4-7-0 against the spread this season.
• This year, the 49ers are winless against the spread when entering a game as an underdog of 6 points or more.
• This year, San Francisco games have hit the over six times.
• The 49ers lost the only game they’ve played as the underdog this season.
• The 49ers have a 32.3% chance to win this game based on the implied probability of the moneyline.

ATBForum Selection: Bills (-7)